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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.panaloko free 100 no deposit bonus 。

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Manchester United’s decision to put up the cost of all members’ match tickets to £66 for the remainder of the season has been labelled “offensive” by the club’s leading supporters’ group. Manchester United Supporters’ Trust (MUST) revealed the club had informed the fans forum that changes to certain ticket policies will take effect immediately “and that this price will apply for kids and over-65s as well as adults”. The news comes as the club confirmed the cost of paying off former manager Erik ten Hag and his staff was £10.4million, while a release clause to bring in new head coach Ruben Amorim and his staff amounted to £11m. The figures were part of a longer version of the club’s first-quarter accounts which were released to the New York Stock Exchange on Wednesday. United and Everton fans are set to stage a protest against ticket prices ahead of their Premier League clash on Sunday. Supporters are being asked to gather next to the trinity statue outside Old Trafford to support the Football Supporters’ Association’s ‘Stop Exploiting Loyalty’ campaign. As well as increasing prices generally, fans are unhappy about the removal of concession tickets for certain groups. An MUST statement read: “Suffice it to say that the idea that the fans must pay their ‘fair share’ for the club’s excesses and/or mismanagement — and above all, the Glazers’ lack of investment over two decades — is offensive. “We fans have done everything we have been asked. We have cheered the players on even in the face of substandard performance. “We have objected to this action in the strongest possible terms, both for the action itself and the complete lack of consultation, which is a step backward based on the process we had agreed with the club before INEOS’ arrival. “Over the coming days MUST will be seeking urgent discussions with the club to get them to listen to fans’ concern at this policy. “United fans have sucked up a lot. We will not be silent on this and we need to be prepared to resist any attempts to further drive up ticket prices.” Supporters’ group The 1958 said along with United and Everton, both Liverpool and Manchester City supporters will also display an FSA banner ahead of their match on Sunday. “With 19 out of 20 Premier League clubs increasing ticket prices this season, FC58, Everton, Liverpool and City supporters will display the FSA banner to raise awareness that any future season ticket price increases, removal of concessions, and treating match-going supporters as an easy target to make quick revenues will not be tolerated,” the fans’ group said. “With the discussions around the rebuild or redevelopment of Old Trafford, we need to send a message to the club that we are laser focused on keeping football affordable and looking after our loyal, match-going fan base. “Manchester United have announced that they will be selling tickets to members for the remainder of the season at a minimum of £66 irrespective of if you are under 16, youth, OAP or disabled, which is a clear exploitation of the loyal fan base and their first move towards dynamic pricing.”One of the key advantages of CIBTC is its ability to facilitate transactions across different industries and regions. Participants can trade goods and services ranging from agriculture to technology, from domestic to international markets. This diversity allows for greater flexibility and adaptability in meeting the needs of both buyers and sellers. Moreover, CIBTC's advanced technology and system ensure smooth and transparent transactions, enhancing trust and confidence among participants.

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The Supreme Court has dismissed three Fundamental Rights Applications Nos. 198/2024, 254/2024, and 263/2024, which challenged the opening of the Initial Public Offering (IPO) of LTL Holdings Ltd., on the Colombo Stock Exchange (CSE). Upon hearing the submissions of all the Petitioners and the Respondents, the Supreme Court before Chief Justice Murdu N.B. Fernando, PC and Justice E.A.G.R. Amarasekara refused to grant leave to proceed and dismissed all three cases. LTL Holdings was on course to complete the biggest IPO worth Rs. 20 billion before the litigation. In September LTL launched its IPO primarily to support two major projects — Rs. 13.5 billion will be utilised to part finance the equity investment towards the construction of a 350 MW combined cycle power plant in Kerawalapitiya (Sahasdhanavi Ltd.), which would be the second power plant to operate on LNG in Sri Lanka and Rs. 6 billion towards investing in a 50% equity stake in the 100 MW Siyambalanduwa Solar Power Project Rividhanavi Ltd. The IPO was for 22.3% stake or 1,379,310,400 new ordinary voting shares at an issue price of Rs. 14.50 per share and aimed to raise Rs. 16 billion, with a green shoe option to increase the total to Rs. 20 billion. The joint managers and financial advisors to the issue are NDB Investment Bank Ltd.Blackbucks and TASK sign MoU for Rs 20-crore investment to empower studentsEgyptian Prime Minister Dr Mostafa Madbouly met in Cairo Wednesday with HE the Qatari Prime Minister and Minister of Foreign Affairs Sheikh Mohammed bin Abdulrahman bin Jassim al-Thani. The meeting dealt with discussing bilateral relations and the means to enhance co-operation in all fields, especially in the political, economic, investment, commercial and humanitarian fields, in a way that meets the aspirations of the two brotherly peoples. The latest developments in the region, especially in the Gaza Strip and the occupied Palestinian territories, were also discussed, in addition to developments in Lebanon.