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RADNOR, Pa., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Certara, Inc. (Nasdaq: CERT), a global leader in model-informed drug development, today showcases its impact on research by celebrating more than 100 publications secured in 2024 as well as the 12 Certara scientists included on the 2024 Stanford/Elsevier list, which highlights the top 2% of the most cited scientists across the globe. Stanford/Elsevier's Top 2% Scientist Ranking Now in its 7 th iteration, the Stanford/Elsevier's Top 2% Scientist Ranking list includes the top and most-cited researchers globally in 22 scientific disciplines and 174 sub-disciplines and encompasses standardized data on citations, h-index, and a wide range of bibliometric indicators. The following Certara researchers appeared on Elsevier’s top 2% of the world’s most-cited researchers list in 2024, highlighting recent and career-long impacts. Amin Rostami-Hodjegan, Chief Scientific Officer at Simcyp Frederic Bois, Senior Scientific Advisor & Head of Mechanistic Modelling Hannah Jones, Senior Vice President, Head of Simcyp PBPK Modelling Services Hugo Geerts, Head of QSP Neurosciences Khaled Abduljalil, Senior Principal Scientist at Simcyp Karen Rowland-Yeo, Senior Vice President, Client & Regulatory Strategy Masoud Jamei, Senior Vice President of Research and Development at Simcyp Piet H van der Graaf, Senior Vice President and Head of Quantitative Systems Pharmacology Patrick Smith, President of Certara Drug Development Solutions Rajesh Krishna, Distinguished Scientist, Drug Development Science Stephen Duffull, Senior Scientific Advisor Trevor Johnson, Principal Scientist at Simcyp "Certara is a science-driven organization, and our scientists are world leaders in their fields. Our clients rely on us to deliver advanced biosimulation software and the expert advice needed to interpret results for optimal strategic decision-making,” said William Feehery, CEO, Certara. 2024 Publications Certara scientists and publications span the entire drug discovery and development process from early discovery through clinical, regulatory, and post-approval. Key highlights and trends evident in 2024 publications are grouped into two primary categories below. Value and Impact of Biosimulation Strategies and Execution in Drug Development Pediatric oncology drug development and dosage optimization Mechanistic modeling’s impact on first-in-human dose predictions and clinical validations thereof Exposure-Response Analyses to Inform Dosing Considerations and Labeling Impact of physiologically-based pharmacokinetics (PBPK) modeling on Global Health The role of pharmacometrics in understanding Variability in Clinical Trials Extended Model-Informed Drug Development: Beyond Clinical Trials and Regulatory Approval Best practices for implementing technologies that streamline drug submission and approval processes Diversity in Clinical Trial Enrollment and meeting requirements of the FDA Diversity Action Plan Using real-world data to inform clinical patient management and treatment guidelines for COVID-19 Unlocking the Synergies of Generative AI in Regulatory Writing Preventing chaos: The Critical Role of the Submission Lead To learn more about Certara’s publications, please visit: www.certara.com/resources/publication About Certara Certara accelerates medicines using biosimulation software, technology, and services to transform traditional drug discovery and development. Its clients include more than 2,400 biopharmaceutical companies, academic institutions, and regulatory agencies across 66 countries. Learn more at certara.com. Certara Contact: Sheila Rocchio sheila.rocchio@certara.com Media Contact: Alyssa Horowitz certara@pancomm.comSan Francisco 49ers quarterback Brock Purdy will not play Sunday and head coach Kyle Shanahan said the lingering discomfort is a concern. Purdy sat out Friday after he participated in the start of Thursday's practice with the 49ers, then retreated indoors for what Shanahan said was a treatment session. Brandon Allen, 32, will start in Purdy's place, and the 49ers are also without defensive end Nick Bosa (oblique). Shanahan said players believe in Allen, even if he's an unknown. "Outside of here people haven't seen a lot of Brandon. But it's his second year (with the 49ers)," Shanahan said. "Obviously guys want Brock up, but guys are excited to see Brandon play." Shanahan said they are "a little surprised" Purdy experienced tightness and discomfort in his shoulder after an MRI exam on Monday that showed no long-term cause for concern. "The way it responded this week, it's really up in the air for next week," Shanahan said of Purdy. Allen is familiar to Packers head coach Matt LaFleur, who was an assistant coach with the Rams during Allen's two-year run in Los Angeles. Allen broke into the NFL in 2016 with the Jaguars and is 2-7 in nine career starts. He went 1-2 with the Broncos in 2019 and 1-5 in six starts over two years with the Bengals in 2020 and ‘21. Shanahan said Allen's confidence grew throughout the week and he doesn't anticipate a major change in how he calls the offense. Left tackle Trent Williams (ankle) also missed practice for the third consecutive day. Without disclosing the nature of the ailment to Purdy's throwing shoulder, general manager John Lynch confirmed Friday an MRI exam took place to determine the severity of any injury. Allen worked with the first team most of Thursday and Friday with Joshua Dobbs also taking snaps. Lynch described Purdy's status for the 49ers (5-5) this week as "tenuous." "Hopefully, he makes progress, and we can have a shot at this weekend, but we'll see," Lynch said in an interview with KNBR in San Francisco. "I think it's tenuous." When Purdy was on the field this week, he primarily worked on the side in position-specific drills with QB coach Brian Griese. Williams played through an ankle injury last week after being listed as questionable but exited the stadium with an exaggerated limp on Sunday. Run game coordinator Chris Foerster said the 49ers aren't where they want to be at 5-5 because they haven't won close games, not because of injuries. "Seven games left is like an eternity," Foerster said. "So much can happen. Do the math. What was our record last year? It was 12-5. I was on a 13-win team that was nowhere near as good as the team last year." With or without Purdy, Foerster said the challenge for the 49ers is not to give up the ball to a defense that has 19 takeaways. The 49ers have 13 giveaways this season. --Field Level Media

WASHINGTON (AP) — Jason Drake had 21 points in Drexel's 68-65 victory over Howard on Tuesday night. Drake shot 8 for 17 (1 for 5 from 3-point range) and 4 of 4 from the free-throw line for the Dragons (8-4). Yame Butler went 6 of 10 from the field (3 for 7 from 3-point range) to add 16 points. Marcus Dockery led the Bison (5-7) in scoring, finishing with 14 points and two steals. Blake Harper added 11 points, nine rebounds and five assists. Cameron Shockley-Okeke had 10 points. Drexel went into halftime leading Howard 36-34. Butler put up 10 points in the half. Drexel used an 8-0 run in the second half to build an 11-point lead at 49-38 with 13:07 left. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Republican U.S. Sen.-elect Tim Sheehy this week claimed a firework-ignited grass fire set near his campaign sign west of Livingston was a politically motivated arson. A Park County sheriff’s deputy on Dec. 21 notified dispatchers of a fire near Interstate 90 and West End Road. On social media, the sheriff’s office said winds that night were clocked at 50-to-60 mph and helped push the fire out to 26 acres. Image of the area west of Livingston burned by someone discharging fireworks into the grass on Dec. 21, 2024. (courtesy Park County Sheriff's Office) Authorities issued evacuations for the nearby residents and firefighters knocked the blaze down in roughly an hour and a half, according to the sheriff’s office post. The fire "definitely" started near a Sheehy campaign sign, the rural fire district chief told the Livingston Enterprise . And while law enforcement has obtained video of the suspect's vehicle fleeing the area after starting the fire, it appeared Friday that no one had been charged yet. Republican U.S. Senate candidate Tim Sheehy addresses supporters early Wednesday morning at the Kimpton Armory Hotel in Bozeman. On Tuesday Sheehy appeared near the scorched scene and issued a social media post of appreciation for the responders, which, according to the Enterprise , included neighbors to the threatened properties. He also posted a picture with two Montana Department of Transportation employees, whose facility was adjacent to the burned area, as well as a photo of a blackened building. Initial reports from the sheriff’s office did say the incident was being investigated as a criminal act but did not imply political motivations, although Sheehy appeared certain of it in a video posted to his social media. "We just visited with the Jensen family here, four beautiful young kids, it was actually their third daughter’s birthday the night that these arsonists started the fire to burn down our sign and started about a 30-acre wildfire, burned their grazing land, harmed their property and its just sad that would happen here," Sheehy said. "We can still disagree, we can still respect each other in this country. We don't have to do things like this." Grateful to the Montanans who helped respond to this fire on Saturday before it did even more damage. While the investigation remains underway, this type of dangerous, reckless violence has no place in Montana. Terrible way for these folks to start the Christmas week, but they... pic.twitter.com/djsWv013TT The Park County Sheriff's Office said on Facebook on Monday it had obtained video evidence of a person shooting a firework out of a moving vehicle and igniting the dry grass before heading west on I-190. "It was definitely someone setting off fireworks at the sign," Park County Rural Fire District Chief Dann Babcox told the Enterprise , referencing law enforcement reports. A call to the sheriff's office on Friday seeking any update or arrest information was not immediately returned. "Very disappointing, really tough way for these families to enter the Christmas week," Sheehy continued in his video. "It's effected several families here, including some structures, its a tough way for these people to have to start the holiday season." Seaborn Larson has worked for the Montana State News Bureau since 2020. His past work includes local crime and courts reporting at the Missoulian and Great Falls Tribune, and daily news reporting at the Daily Inter Lake in Kalispell. Get Government & Politics updates in your inbox! Stay up-to-date on the latest in local and national government and political topics with our newsletter. State Bureau Reporter {{description}} Email notifications are only sent once a day, and only if there are new matching items.

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By Teeuwe Mevissen, senior macro strategist at Rabobank Did we leave behind the cost of living crisis? Obviously this depends on one’ s financial situation but for some money ain’t a thang as Jermaine Dupri would say. Recently the ‘art’ concept ‘ the comedian’ was auctioned via the legendary auction house Sotheby’s. A crypto ‘investor’ is now the new and proud owner of a banana and a roll of silver coloured duct tape. The price? $6.2 million and up from $ 120K in 2019 . This is still peanuts compared to the Magritte that was also auctioned at the other legendary auction house Christie’s and sold at the hefty price of $121 million . More money more problems? Or more money more bananas? It’s likely bananas since it all seems bananas nowadays. Yesterday for instance, Russia rattled it’s nuclear sabre once more because it apparently thinks that it’s only Russia’s privilege to use long range weapons obtained from its pariah partners. This was after the West had to discuss bananas once more to finally decide that certain types of weapon systems could be used by Ukraine - and if so - how. Or maybe instead we should discuss how to end the war in 24 hours without addressing and more importantly solving the true underlying problem(s). Looking at bitcoin one might think that all problems have already been solved. At the moment of writing bitcoin is approaching $100.000 because of expectations of a pro-crypto administration and also indicating that there is plenty of risk appetite in various corners. Stock markets also seem to have brushed off the recent escalation regarding the war in Ukraine with a Dow Jones close to reaching a level of 44,000. But when one takes a look at eurodollar, the exchange rate diving below a level of 1.05 seems to indicate that there is plenty of (geopolitical) risk and market participants are looking for safe havens. Weak data from Europe this morning, obviously are not helpful here. Regardless let’s discuss bananas simply because it’s all bananas. So let’s switch from bananas to economic data which in some cases is actually more related to each other than one might think. While the data calendar of yesterday did not have much to offer, today markets will be offered more insights. UK retail sales volumes fell 0.7% in October, after a revised 0.1% rise in September (down from 0.3%). Monthly retail sales look like a seesaw, often swayed by factors like weather. Over the three months to October 2024, volumes rose 0.8% compared to the three months to July, and 2.4% year-on-year. However, they remain 1.5% below pre-pandemic levels from February 2020, highlighting the lasting impact of weak growth and inflation. Germany’s Q3 growth was revised down to 0.1% q/q from 0.2%. While this still beats the initial forecasts, the economy’s business model is faltering, and storm clouds loom for next year, particularly with Trump tariffs on the horizon. Preliminary data measuring European purchase manager indices paint a harrowing picture of sentiment in both the services as well as in the manufacturing sector. Sentiment in the French services sector dropped sharply and came in much lower than expected (45.7 vs 49 expected). Sentiment in the French manufacturing sector also disappointed coming in at 43.2 vs 44.5 expected). Both indices indicating an economic downturn. The survey also highlighted that ‘cost pressures’ remain a concern (even in France where wage growth is considerably lower than in, for example, Germany). Operational expenses increased at the fastest rate in 3 months, albeit at a limited rate compared to the series average. Many panellists cited higher wages as the main reason for the cost increases. Output charges rose, but this was fully driven by services providers; manufacturing gave discounts to deal with competition. Germany also reported a manufacturing PMI of 43.2 vs 43 expected and sentiment in the services sector dropped to a level of 49.2 where a level of 51.7 was expected. The survey reports uncertainty among panellists, with services providers highlighting fewer new orders from manufacturers. Falling goods production and a lack of incoming new work therefore remains a major drag on overall economic output. This indicates that Germany’s economy is still very much struggling and that a new government will have plenty of issues to deal with.Struggling Coventry families were 'crying tears of joy' when they attended a hugely popular event in the city on Christmas Eve . Thousands flocked to Willenhall Social Club on December 24 as gifts were handed out and children got to meet Santa. Organiser Clel Sneddon came up with the idea 11 years ago to help disadvantaged families in Willenhall . It has since 'spiralled' into one of the biggest free-to-attend events in the West Midlands. Families from Willenhall , Binley , Whitley , and Ernesford Grange were given Cadbury Selection Boxes and Nintendo Switches. Children also had the chance to meet Father Christmas. READ MORE: CCTV captures moment brazen fly-tippers dump mattress in Coventry Clel, who runs the Pride of Willenhall on Facebook , said the idea for the hugely popular event stemmed from giving away a food hamper in 2013. Over 1,400 nominations were received, which the 51-year-old described as 'staggering.' It then 'spiralled' into the hugely popular event, which is held every year on Christmas Eve . Clel said the free-to-attend event is always a team effort which comes together with the help of Angela Odea, Rob O'Toole, Dougie Walton, Martin Carolan, and Katie Jonas. Queues at the Willenhall Social Club this year were said to be 'unbelievable.' Clel said: “We just thought there is a need for this, the community needs this, and each year, it has just grown to what you saw on Christmas Eve .” Children from disadvantaged backgrounds had the opportunity to meet Santa Claus, with many saying they were just 'blown away.' Around 1,500 brand-new toys were handed out on the day, including Nintendo Switches. Gifts were also donated to University Hospital Coventry in Walsgrave . One woman who won a bicycle for her son was in such disbelief that she started crying. Clel said: “She just could not believe that she was taking away a new bike to give to her son for Christmas .” Clel told CoventryLive that he started the event to bring Christmas joy to disadvantaged families in Willenhall . He said: “You will have people turning up who that might be their only opportunity to actually see Father Christmas.” He added: “Again, there are people who will turn up, and it might be the only presents they receive this Christmas . We made sure kids left fully stocked up with presents, chocolates, and everything else! It shows the good in Willenhall .” Sign up for our FREE daily newsletter here for all the latest news about Coventry .Town halls are to be given sweeping powers to issue on-the-spot fines for minor misdemeanours such as climbing trees in parks. Currently, councils trying to bring in local laws need to get a sign-off from a government minister. But under plans submitted in white paper on English devolution, local authorities would not have to get such permission and could be given the power to issue more fixed penalty notices rather than take people to court as at present. Councils already have limited – but highly controversial – powers to issue on-the-spot fines for misdemeanours such as littering and fly-tipping. But critics say the proposed new rules, which will massively increase the number of fixed penalty notices, could lead councils to abuse their powers and introduce byelaws to stop people smoking in the streets and selling unhealthy food in public places. could also use their proposed new powers to raise much-needed money. , the shadow local government secretary, said: “The Labour Government will leave no stone unturned in their mission to pick people’s pockets. “These proposals also raise serious concerns about civil liberties by opening the door to allowing overzealous town hall officials to ban lawful innocent activities in public places, such as vaping, walking a dog or going on an organised group run. “The justice system should not be hijacked to line the taxman’s pockets.” At present, on-the-spot fines issued by a local authority are typically between £50 and £100. Councils have previously been criticised for raking in millions in parking fines. Last year, councils collected £620 million – with Lambeth council in London alone collecting £52.4 million. Josie Appleton, director of the civil liberties group Manifesto Club, said: “I’m worried that councils will use these , as they do with other powers that allow fixed penalty notices. “Increasingly councils are employing private enforcement officers who are paid per fine, and will issue penalties whenever possible. “There are lots of archaic byelaws on the books, so we can expect people to be penalised for public nuisance, playing music or ball games in a park.” The Conservatives ruled out such a move during the coalition government because of the risk that councils would use the nanny-state fines to raise money – or outsource the work to private firms. They say that based on current council byelaws across the country, it could lead to fines for walking more than one dog at a time, ball games, use of model aircraft and kites and “informal” football or cricket. Last year two councils – Torfaen in Wales and Rugby – were criticised for using anti-social behaviour powers to ban the climbing of trees in some protected public spaces. The white paper also raises fears that new byelaws – introduced without secretary of state sign-off – could ban smoking in outdoor areas and outlaw unhealthy food being sold in public places. Angela Rayner’s white paper said the process for making byelaws is hundreds of years old and outdated for modern government. It said it was irrational for the Communities Secretary to have to agree before councils can set rules on “where people can ride bikes or climb trees in parks”. “This is irrational, inefficient and costly – tying up central government in decisions that should be for local leaders.” “We believe that to understand and respond to these issues. We intend to legislate to remove requirements for Secretary of State consent for local authority making of byelaws wherever possible. “Given the complexity of legislation that has built up over many decades and the wide policy scope under consideration, we will accomplish this through a review of such cases. “As part of this review, we will also determine whether councils should be able to enforce byelaws via fixed penalty notices rather than through the courts to improve their effectiveness. “We will consult the sector to agree on the best approach on how we might accomplish this.” Last night a spokesman for the Ministry of Housing, Communities and Local Government said: “We will work with councils to review whether they should be able to enforce byelaws via fixed penalty notices to improve their effectiveness.”GE Vernova announces first H-Class order in the Caribbean (December 16, 2024) GE Vernova Inc. (NYSE: GEV) today announced it has secured an order to provide its H-Class natural gas-fired combined cycle power generation equipment for Generadora San Felipe Limited (GSF)’s Sant Felipe 470 megawatts (MW) plant power station in Punta Caucedo, Boca Chica, Dominican Republic. This project marks GE Vernova’s first H-Class gas turbine order in the Caribbean. It will contribute to the implementation of Dominican Republic’s climate ambitions and sustainable development goals by supporting the rapid expansion of renewable energy through its dispatchable power profile. The Caribbean country, one of the fastest growing economies in Latin America, has in recent years managed to switch most of its oil-fired generation capacity to natural gas. Natural gas accounts for nearly half of all energy generated in the Dominican Republic and plays a crucial role in the country’s energy transition, as it supports and complements the expansion of renewable sources. Natural gas-fired combined cycle power plants are the fossil fuel power plants, whether measured based on CO2, SOx, NOx, particulate matter, or mercury. General Manager of Generadora San Felipe, said : “We trusted the solid reputation of HA technology and turned to GE Vernova, an innovation leader in the path towards decarbonization, based on a longtime collaboration between our two companies.” The new San Felipe power plant features one multi-shaft generating block, equipped with GE Vernova 7HA.02 gas turbine coupled to an H65 generator, an STF-A650 steam turbine coupled to an H35 generator, a triple pressure with reheat Heat Recovery Steam Generator (HRSG), and a condenser. President of GE Vernova’s Gas Power in the Americas region, said : “Once completed, the power plant is expected to be among the most efficient power plant in the Caribbean and can be configured with post-combustion carbon capture systems to significantly reduce carbon dioxide emissions. In addition, our GE Vernova HA gas turbine is highly fuel flexible and able to operate on a variety of fuels, including blends of hydrogen and natural gas to offer multiple pathways to reduce carbon emissions and work towards near-zero operations in the next decade.” With the highest number of H-Class units achieving commercial operation, GE Vernova’s HA gas turbines have accumulated more than 2.5 million commercial operating hours continuing to be the fastest growing fleet in the heavy-duty gas turbine H-Class segment. The fleet boasts an installed capacity of more than 53 gigawatts (GW) of power, the equivalent capacity needed to power nearly 40 million American homes. HA gas turbines can save over 3.3 metric tonnes of CO2 emissions per year, per unit compared to an average coal-fired plant of the same size. This is equivalent to removing 680,000 cars off the road for every HA unit deployed. San Felipe power plant, built by the Spanish engineering procurement construction (EPC) company TSK Electrónica y Electricidad S.A. (Grupo TSK), is expected to start its operation in 2027. The plant is located next to AES/ENADOM LNG terminal, with a total storage capacity of LNG of 250,000 m3. the latest news shaping the hydrogen market at GE Vernova announces first H-Class order in the Caribbean, Pioneering Hydrogen-Powered River Vessel in France Marking a groundbreaking milestone in sustainable transport, the Sogestran Group launched the ZULU 06, France’s first hydrogen-powered river vessel, on the Seine... NAVANTIA completes the fitting of the hydrogen propulsion system AIP into a S-80 class submarine Navantia’s shipyard in Cartagena has completed the installation of the Hydrogen based Air Independent Propulsion... France’s First Hydrogen-Electric Powered Fishing Training Vessel Ready to Set Sail The LPMA: Maritime and Aquaculture Professional School of Bastia will on November 15, 2024, inaugurate France’s first...